PicoFrit® Columns: The Ultimate LC-MS Proteomics Platform
At flow rates of nL/min versus mL/min, nanospray offers higher sensitivity with greater signal-to-noise ratio
than traditional microspray. Engineered specifically for nanobore-LC, PicoFrit® columns offer the dependability
of a pre-packed column with the convenience and efficiency of an integrated frit and tip. Eliminate post-column
losses by spraying directly from the column.
PicoFrit® Benefits
- Eliminates band broadening
- Sprays directly from column to inlet
- Minimizes post-column loss
- Integral frit greatly reduces tip clogging
- Robust performance compatible with automated systems
- High-resolution separations yield femtomole sensitivity
The PicoFrit® Advantage
Spraying directly off the column boosts the performance of your mass spectrometer compared to that provided by a column
attached to a tip. Less time spent making connections increases efficiency. That's the PicoFrit® advantage.
| Standard column coupled with a tip |
PicoFrit®column |
 |
- Ion chromatograms for full-scan MS data of 4 angiotensin variants at 25 fmol injected on column
- The chromatogram at left was obtained using a C18-packed column coupled to a coated emitter with a union
- The chromatogram at right was obtained using a C18-packed
PicoFrit® column (75 µm ID/15 µm
tip ID)
- The PicoFrit column yielded better peak shape with decreased peak width, resulting in higher sensitivity
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